Study of higher brain dysfunction of cerebrovascular and neurodegenerative diseases and lesion localization and disability networks

Study of higher brain dysfunction of cerebrovascular and neurodegenerative diseases and lesion localization and disability networks

Higher cerebral dysfunction, such as aphasia, loss, disablation, memory impairment, half-space obsolescence, and performance dysfunction, caused by cerebrovascular and neurodegenerative diseases, have a significant impact on daily life, and diagnosis and intervention treatment from early onset is very important for improving the quality of life of patients. On the other hand, there are many unclear points about the mechanism and neural base of these higher brain dysfunctions, and it is expected that a simple biomarker for early diagnosis will be developed.
Against this background, dis-connectome analysis using brain image analysis such as diffusion tensor images and resting functional MRI has attracted attention in recent years as a new disease biomarker. This analysis method considers the brain as a network and examines the localization and distribution of networks damaged by the lesion, so that it is possible to capture the pathology more quickly and precisely compared to conventional analysis focusing only on lesion localization.
Therefore, in this study, we conduct these new brain image analysis for neuronal diseases, mainly cerebrovascular disorders, to evaluate brain network disorders related to various higher brain dysfunctions, and develop new disease biomarkers that can be applied to early diagnosis of disorders and disease assessment.

The acknowledgement cerebral cerebral dysfunction (cerebral infarction, cerebral hemorrhage, etc.) and 100 neurodegenerative diseases such as Parkinson's disease, spinal cord dermatosis, and amyotrophic lateral sclerosis, and 100 healthy volunteers who match age, gender, and educational history.
In addition, we will collect MRI lesions and various clinical indicators from a backward perspective targeting 300 cases of cerebrovascular disorders who have visited or hospitalized at our hospital and joint research institutions, and conduct studies using dis-connectome analysis (backward observation research: using only existing medical information).

It covers cases of cerebrovascular disease and neurodegenerative disease who have been hospitalized or hospitalized at our hospital and joint research institutions, or who have obtained research consent, and healthy persons who have obtained consent to the research.

From the date of permission to March 31, 2027

We will use the test results and brain image imaging data of those who have agreed to this study. In addition, we collect information related to MRI lesions and various clinical indicators from existing medical information.

When storing correspondence tables and other personal information in electronic data, documents and records related to this study (records of the Ethics Committee, written consent documents, case reports, etc.) with passwords are stored on an independent computer device that is not connected to the hospital LAN or the Internet, and when stored on paper, they are strictly managed in a bookshelf that can be bound and locked in a file, and stored in such a way that anyone other than researchers involved in this study cannot access. In addition, at least five years from the end date of this study or three years from the date on which the final publication of the results of this study is reported, whichever is later.
The information provided to Yokohama City University and Yokohama New Urban Neurosurgery Hospital, which are joint research institutions, is submitted with a password on the accumulated data. Yokohama City University and Yokohama New Urban Neurosurgery Hospital maintain this research plan as a record of the transfer and receipt of existing information (the institution providing it; three years after providing the information; five years after the end of the research), and aggregate anonymous data from each facility using a password-protected USB. The data provided will be stored on an offline PC within the joint institution.
In addition, when discarding after the expiration of the storage period, the information stored in electronic media will be erased in a form that cannot be restored from the stored computer terminal, etc., and the information stored in paper media will be shreddered. Discard.

This study is an observational study, and no serious adverse events are assumed.
MRI examinations are conducted in accordance with our facility safety standards, but if you carry metals and electronic devices, etc., which are prohibited from bringing them into MRI rooms, heat will be generated due to the magnetic effects of MRI. May have a negative effect on the body.
Also, the noise generated during MRI imaging and the closedness of MRI scanners can cause mental stress. To minimize these risks, we will explain the MRI notes in advance and carefully check if you are not wearing anything that is prohibited from being brought in before actually entering the MRI room. The noise is reduced by wearing ear plugs and headphones as necessary until it feels within the tolerance range. In addition, from outside the laboratory, we constantly monitor the condition of the subject and call out through indoor speakers frequently to relieve mental distress.
In addition, psychological and physical fatigue due to psychological tests is also assumed, so if necessary, we will provide appropriate rest, such as providing appropriate rest.

If you have any questions or concerns about this research, please contact the following address.
If you wish, you can browse the research plan and related materials to the extent that it does not interfere with the protection of personal information and intellectual property of other research subjects, so please contact us by telephone or fax.
In addition, if the patient or the patient's proxy/agent does not understand that the sample or information is used in the research, it will not be included in the research. Please contact the following address. Even in that case, there is no disadvantage to the patient.

〒235-0012 1-2-1, Takigashira, Isogo-ku, Yokohama-shi, Kanagawa
Yokohama City Apolexy and Spinal Nerves Center Neuroscience Internal medicine
Dr. Yuichi Higashiyama
TEL: 045-753-2500 (Representative)