Study on the frequency of demyeling and axon degeneration in peripheral nerve biopsy and skin biopsy

　Study on the frequency of demyeling and axon degeneration in peripheral nerve biopsy and skin biopsy

　Peripheral neuropathy (neuropathy) is known to be caused by various factors. Diagnosis of the causative disease often enables treatment according to the condition, and early and accurate diagnosis is important.

　Neurobiopsy can not only directly prove the presence of vascularitis and amyloids, but also estimate the causative disease based on the presence or absence of demyeling or axon degeneration, and is a useful test for diagnosis of peripheral neuropathy. Traditionally, from a pathological point of view, peripheral neuropathy can be roughly classified into demyelative neuropathy and axon-degenerative neuropathy. However, the pathological conditions that cause demyeling and axon degeneration are diverse, and both are often mixed, so diagnosis was often difficult.

　In this study, we calculate the ratio of demyeling and axon-degeneration neurofibers in individual cases using existing biopsy samples, and examine a number of cases to clarify the relationship between demyeling and axon-degeneration ratios and causative diseases. Specifically, the ratio of demyeling and axon-degeneration nerve fibers is calculated using a loose specimen obtained by a fibula abdominal nerve biopsy. The evaluation of non-myeling fibers in the epidermis is performed using the skin collected at the same time as the neurobiopsy.

　Patients who are suspected of neuropathy and need to undergo neurobiopsy, or who have already undergone neurobiopsy.

　Until March 31, 2043

　Get information about the following items.

　1.Patient ID
　2.Age
　3.Gender
　4.Height
　5.Weight
　6.Name of diagnosis
　7.Medical history
　8.Family history
　9.Life history
　10.Complications
　11.Neural findings
　12.Blood test results
　13.Cerebrospinal fluid test results
　14.Neuroconductivity Test
　15.Findings of fibula abdominal nerve pathology
　16.Non-spinal fiber density in the epidermis

　This research is a multi-institutional joint research with the Neuroscience Internal medicine, Saga University Hospital, and the acquired information is provided to the Neuroscience Internal medicine of Saga University Hospital.

　All information is anonymized so that individuals cannot be identified. In addition, the information obtained will be kept appropriately until 5 years after the report of the end of the study or 10 years after the report on the final publication of the results, whichever is later, and will be discarded after the individual cannot be identified.

　There is no burden or risk of being subject to this study. At the same time, there is no profit.

　If you have any questions or concerns about this research, please contact the following address.
　If requested, it will not interfere with the protection of personal information and intellectual property of other research subjects.
　You can browse the research plan and related materials, so please contact the following contact information by telephone or fax.
　In addition, if the patient or the patient's proxy/agent does not understand that the sample or information will be used in the research, please contact us.
　As it is not a subject of research, please contact the following address. Even in that case, there is no disadvantage to the patient.

　〒235-0012 1-2-1, Takigashira, Isogo-ku, Yokohama-shi, Kanagawa
　Yokohama City Apolexy and Spinal Nerves Center Neuroscience Internal medicine
　Ken Shirokura
　TEL: 045-753-2500 (Representative) FAX: 045-753-2859